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orcid.org/0000-0002-8939-5445

• Disease prediction with multi-omics and biomarkers empowers case–control genetic discoveries in the UK Biobank
  M Garg, M Karpinski, [13 authors], RS Dhindsa, S Petrovski,  D Vitsios
  Nature Genetics 56, 1821–1831, (2024)


• Phenome-wide identification of therapeutic genetic targets, leveraging knowledge graphs, graph neural networks, and UK Biobank data
  L Middleton, I Melas, C Vasavda, [9 authors], D Vitsios
  Science Advances 10 (19), eadj1424 (2024)


• Rare variant associations with plasma protein levels in the UK Biobank
  RS Dhindsa, [16 authors], B Challis, A Platt, D Vitsios, EA Ashley, CD Whelan, MN Pangalos, Q Wang, S Petrovski
  Nature 622, 339–347 (2023)


• Applying Machine Learning on UK Biobank biomarker data empowers case-control discovery yield
  M Garg, M Karpinski, D Matelska, L Middleton, J Mitchell, A O’Neill, Q Wang, AR Harper, RS Dhindsa, S Petrovski, D Vitsios
  medRxiv 10.23296832 (2023)


• Effects of protein-coding variants on blood metabolite measurements and clinical biomarkers in the UK Biobank
  A Nag, RS Dhindsa, L Middleton, X Jiang, D Vitsios, [10 authors], S Petrovski
  The American Journal of Human Genetics 110 (3), 487-498 (2023)


• Cancer-driving mutations are enriched in genic regions intolerant to germline variation
  D Vitsios, RS Dhindsa, D Matelska, J Mitchell, X Zou, J Armenia, F Hu, Q Wang, B Sidders, AR Harper, S Petrovski
  Science Advances 8 (34), eabo6371 (2022)


• DrugnomeAI: An ensemble machine-learning framework for predicting druggability of candidate drug targets
  A Raies, E Tulodziecka, J Stainer, L Middleton, R Dhindsa, P Hill, O Engkvist, A Harper, S Petrovski, D Vitsios
  Communications Biology 5 (1), 1291 (2022)


• Human genetic evidence supports MAP3K15 inhibition as a therapeutic strategy for diabetes
  A Nag, R Dhindsa, AR Harper, D Vitsios, [13 authors], MN Pangalos, S Petrovski
  Science Advances 8 (46), eadd5430 (2022)


• A minimal role for synonymous variation in human disease
  RS Dhindsa, Q Wang, D Vitsios, OS Burren, F Hu, JE DiCarlo, L Kruglyak, DG MacArthur, ME Hurles, S Petrovski
  The American Journal of Human Genetics 109 (12), 2105-2109 (2022)


• Gene-SCOUT: identifying genes with similar continuous trait fingerprints from phenome-wide association analyses
  L Middleton, AR Harper, A Nag, Q Wang, A Reznichenko, D Vitsios*, S Petrovski*
  Nucleic Acids Research https://doi.org/10.1093/nar/gkac274 (2022)


• Rare variant contribution to human disease in 281,104 UK Biobank exomes
  Q Wang, [5 authors], D Vitsios, [11 authors], S Petrovski
  Nature 597 (7877), 527-532 (2021)


• Prioritizing non-coding regions based on human genomic constraint and sequence context with deep learning
  D Vitsios, R Dhindsa, L Middleton, A Gussow, S Petrovski
  Nature Communications 12 (1), 1-14 (2021)


• Identification of a missense variant in SPDL1 associated with idiopathic pulmonary fibrosis
  R Dhindsa, [7 authors], D Vitsios, [18 authors], S Petrovski
  Communications Biology 4 (1), 1-8 (2021)


• Mantis-ml: Disease-Agnostic Gene Prioritization from High-Throughput Genomic Screens by Stochastic Semi-supervised Learning
  D Vitsios, S Petrovski
  The American Journal of Human Genetics 106 (5), 659-678 (2020)


• Exome-based rare-variant analyses in chronic kidney disease
  SC Christie, [3 authors], D Vitsios, [15 authors], A Gharavi
  Journal of the American Society of Nephrology 30 (6), 1109-1122 (2019)


• A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis
  M Morgan, [6 authors], D Vitsios, [6 authors], Donal O’Carroll
  Cell Research https://doi.org/10.1038/s41422-018-0128-1 (2019)


• Mirnovo: genome-free prediction of microRNAs from small RNA sequencing data and single-cells using decision forests
  DM Vitsios, E Kentepozidou, L Quintais, E Benito-Gutiérrez, …
  Nucleic Acids Research 45 (21), e177-e177 6 (2017)


• mRNA 3’uridylation and poly (A) tail length sculpt the mammalian maternal transcriptome.
  M Morgan, C Much, M DiGiacomo, C Azzi, I Ivanova, DM Vitsios, J Pistolic, …
  Nature 548 (7667), 347-351 24 (2017)


• A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming
  L Vasiliauskaitė, D Vitsios, RV Berrens, C Carrieri, W Reik, AJ Enright, …
  Nature Structural & Molecular Biology 24 (7), 604 5 (2017)


• BioPAXViz: a cytoscape application for the visual exploration of metabolic pathway evolution
  FE Psomopoulos*, DM Vitsios*, S Baichoo, CA Ouzounis
  Bioinformatics 33 (9), 1418-1420 4 (2017)


• In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering
  Q Wu, QRV Ferry, TA Baeumler, YS Michaels, DM Vitsios, O Habib, …
  Nature Communications 8 (1), 2109 3 (2017)


• Large-scale analysis of microRNA expression, epi-transcriptomic features and biogenesis
  DM Vitsios, MP Davis, S van Dongen, AJ Enright
  Nucleic Acids Research 45 (3), 1079-1090 21 (2016)


• Chimira: analysis of small RNA sequencing data and microRNA modifications
  DM Vitsios, AJ Enright
  Bioinformatics 31 (20), 3365-3367 34 (2015)